XIAFLEX and Peyronie's disease

Xiaflex is the first FDA-approved drug for the treatment of Peyronie's disease. The drug, collagenase clostridium histolyticum, had previously been approved as a treatment for Dupuytren's contracture. Xiaflex acts by breaking up the collagen scar tissue and allowing for remodeling of the scar with improvement of the penile curvature. Candidates for Xiaflex injection would be a man with stable disease, Peyronie's disease for at least 12 months and a curvature of 30 degrees or more. Xiaflex is a product of Auxilium pharmaceuticals. Xiaflex is available through urologists participating in the REMS program for Peyronie's Disease.